Endocrine Abstracts

Introduction: In Romania, the prevalence of postmenopausal osteoporosis in urban centers was estimated by a study in 2007 to be 16.5%. Using alendronate we are increasing bone mineral density and reducing bone turn-over in women with postmenopausal osteoporosis.Materials and methods: There were examined 55 postmenopausal women with osteoporosis (average age 62±4.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer ...

Aim: To evaluate the effect of risedronate vs ibandronate in treatment of systemic osteoporosis in postmenopausal women.Materials and methods: We examined 57 postmenopausal women with systemic osteoporosis (average age 61±3.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer (HOLOGIC Delphi W; SN 7044909) on lumbar spine. Examination was performed before the onset of treatment and after a period of 1, 2 and 3 year...

The last decade has provided major progress in the development of highly specific and selective pharmacological agents that have facilitated a more aggressive approach to the treatment of patients with acromegaly. Initial transsphenoidal surgery still appears to be the first line of treatment, but in many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Somatostatin analogues have become the mainstay of the medical treatment of acromeg...

Cushing’s disease is relatively rare and affects most commonly adults aged 20 to 40. It is associated with high morbidity and mortality; early detection and diagnosis of Cushing’s disease may lead to decreased this two facts and improved quality of life.We present a 32-year-old man with abdominal purple striae, central obesity with typical ‘moon face’ and oscillatory blood pressure values.Hormonal exams revealed...

Hypovitaminosis D is frequent in population over 65 years age, producing a secondary hyperparathyroidism, increase the bone remodeling, bone loss and osteoporotic fractures, loss of the muscle force.Daily dose of 0.5 μg alfacalcidol was effectively in improved muscle strength in elderly and reduced falls. The bisphosphonates have been shown to increase Bone Mineral Density (BMD) and reduce bone turnover in postmenopausal osteoporosis. The combined a...